This review summarizes recent advances pretreatment of lignocellulose and in the formation and classification of inhibitos from lignocellulosic feedstocks. Furthermore, the various approaches of lignocellulose detoxification contrasted affect at technologies and mechanisms. Physical treatments are simple and low cost, and partid decrease content of acetic acid or furfural. Chemical treatments may added chemical agents to the slurries from extraneous, it uesd to removal furan aldehydes and phenolic. Biological treatments with microorganisms or enzymes to degradation in inhibitors. It may be carried out mild environmental conditions, but treatment time is meas ured in terms of hours or days. Finally, make suggestions on how to improve the utilization efficiency of lignocellulose.